Research on language processing has shown that the disruption of conceptual integration gives rise to specific patterns of event-related brain potentials —N400 and P600 effects. Here, we report similar ERP effects when adults performed cross-domain conceptual integration of analogous semantic and mathematical relations. In a problem-solving task, when participants generated labeled answers to semantically aligned and misaligned arithmetic problems, the second object label in misaligned problems yielded an N400 effect for addition problems. In a verification task, when participants judged arithmetically (...) correct but semantically misaligned problem sentences to be “unacceptable,” the second object label in misaligned sentences elicited a P600 effect. Thus, depending on task constraints, misaligned problems can show either of two ERP signatures of conceptual disruption. These results show that well-educated adults can integrate mathematical and semantic relations on the rapid timescale of within-domain ERP effects by a process akin to analogical mapping. (shrink)

BackgroundFinancial compensation of research participants has been standard practice for centuries, however, there is an ongoing debate among researchers and ethicists regarding the ethical nature of this practice. While these debates develop ethical arguments and theories, they fail to incorporate input from those most affected by financial compensation: potential research participants.MethodsTo identify attitudes surrounding clinical research, participants of a long-standing cohort completed a one-time interview. Open-ended questions stimulated a participant-driven discussion surrounding medical research. Following a grounded theory methodology, 58 semistructured (...) interview transcripts were coded, focusing on attitudes surrounding financial compensation of research participants.ResultsOf the interviews coded, the majority of participants identified as Black/African American and were women. Five major themes emerged. In support of financial compensation, participants felt that study participants should be compensated for time, effort and risk. However, participants were concerned that compensation may differentially impact low-income populations and entice them to hide potentially harmful side effects. Participants also mentioned that financial compensation may invalidate study results if participants knowingly provide false information to subvert inclusion/exclusion criteria.ConclusionThe emergence of both positive and negative themes reiterates the complicated issue of providing financial compensation for study participation. While compensation as a motivator for research participation raises ethical concerns, participants discussed weighing the benefits with the risks in order to make an informed decision. To avoid paternalistic behaviours, research staff must allow potential research participants to review the available information and make the decision that best reflects their wishes. (shrink)

Background Financial compensation of research participants has been standard practice for centuries, however, there is an ongoing debate among researchers and ethicists regarding the ethical nature of this practice. While these debates develop ethical arguments and theories, they fail to incorporate input from those most affected by financial compensation: potential research participants. Methods To identify attitudes surrounding clinical research, participants of a long-standing cohort completed a one-time interview. Open-ended questions stimulated a participant-driven discussion surrounding medical research. Following a grounded theory (...) methodology, 58 semistructured interview transcripts were coded, focusing on attitudes surrounding financial compensation of research participants. Results Of the interviews coded, the majority of participants identified as Black/African American and were women. Five major themes emerged. In support of financial compensation, participants felt that study participants should be compensated for time, effort and risk. However, participants were concerned that compensation may differentially impact low-income populations and entice them to hide potentially harmful side effects. Participants also mentioned that financial compensation may invalidate study results if participants knowingly provide false information to subvert inclusion/exclusion criteria. Conclusion The emergence of both positive and negative themes reiterates the complicated issue of providing financial compensation for study participation. While compensation as a motivator for research participation raises ethical concerns, participants discussed weighing the benefits with the risks in order to make an informed decision. To avoid paternalistic behaviours, research staff must allow potential research participants to review the available information and make the decision that best reflects their wishes. (shrink)

BackgroundJunior medical doctors have a key role in discussions and decisions about treatment and end-of-life care for people with dementia in hospital. Little is known about junior doctors’ decision-making processes when treating people with dementia who have advance care directives, or the factors that influence their decisions. To describe among junior doctors in relation to two hypothetical vignettes involving patients with dementia: their legal compliance and decision-making process related to treatment decisions; the factors influencing their clinical decision-making; and the factors (...) associated with accurate responses to one hypothetical vignette. MethodA cross-sectional survey of junior doctors, including trainees, interns, registrars and residents, on clinical rotation in five public hospitals located in one Australian state. The anonymous, investigator-developed survey was conducted between August 2018 and June 2019. Two hypothetical vignettes describing patients with dementia presenting to hospital with an ACD and either: bacterial pneumonia; or suspected stroke were presented in the survey. Participants were asked to indicate whether they would commence treatment, given the ACD instructions described in each vignette.ResultsOverall, 116 junior doctors responded. In Vignette 1, 58% of respondents selected the legally compliant option. Participants who chose the legally compliant option perceived ‘following patient wishes’ and ‘legal requirements to follow ACDs’ as equally important reasons for complying with the ACD. The most common reason for not selecting the legally compliant option in Vignette 1 was the ‘ACD is relevant in my decision-making process, but other factors are more relevant’. In Vignette 2, 72% of respondents indicated they would commence treatment and 18% selected they would not commence treatment.. Similar reasons influenced participant decision-making in Vignette 2, a less legally certain scenario.ConclusionsThere are critical gaps in junior doctors’ compliance with the law as it relates to the implementation of ACDs. Despite there being differences in relation to the legal answer and its certainty, clinical and ethical factors guided decision-making over and above the law in both vignettes. More education and training to guide junior doctors’ clinical decision-making and ensure compliance with the law is required. (shrink)

This paper explores naturalism and supernaturalism as modes of disclosure that reveal and conceal different aspects of relationality. Naturalism is presented as a worldview or set of philosophical assumptions that posits an objective world that is separable from persons and discoverable or describable via scientific methods. Because psychotherapy tacitly endorses many naturalistic assumptions, psychotherapy relationships may be limited to an instrumentalist ethic premised upon use-value and manipulability. Given these naturalistic limitations, relationships may require a supernatural component – a component which (...) reaches beyond the naturalistic and into the miraculous. The alternative grounding for this supernatural disclosure is found in the philosophy of Martin Heidegger and that of Emmanuel Levinas, the former emphasizing the possibilities inherent in contemplative rather than calculative disclosures, and the latter emphasizing ethical obligation and absolute otherness. A therapeutic case is discussed as an exemplar of both kinds of relational disclosure – that is, naturalistic and supernaturalistic – and the therapeutic and relational consequences of each type of disclosure are explored. Indo-Pacific Journal of Phenomenology, Volume 10, Edition 2, October 2010: 73-85. (shrink)

Reviews the book, The psychology of existence: An integrative, clinical perspective by Kirk Schneider and Rollo May . In light of what they see as a growing interest in existential psychology among training clinicians and researchers, Schneider and May have authored a text which introduces the existential movement and outlines clinical applications of existentialism in psychotherapy. The text's most significant contribution is the latter—the presentation of a guiding clinical framework for conducting the "existential- integrative approach" in psychotherapy. While many personality (...) and psychotherapy texts include introductory chapters about existentialism, few discuss how therapy cases are conceptualized and conducted from an existential therapeutic orientation. This text is an important contribution to the clinical psychology training literature. In traditional clinical training programs, existential approaches to psychotherapy are often overlooked, because such approaches are viewed as purely philosophical rather than clinically applicable. Schneider and May challenge this view. 2012 APA, all rights reserved). (shrink)

Explores a postmodern criticism of P. S. Churchland's claims regarding materialism. Materialism is classically understood to be the philosophical position which holds that matter is the fundamental reality of the world, and so neurobiological explanations can be said to be materialistic. Neurobiological explanations of behavior are used increasingly in the place of psychological explanations. This trend is indicative of the rise in popularity of materialism. Churchland is one of the intellectual leaders in the modern manifestation of materialism. She is a (...) self-proclaimed materialist and "neurophilosopher." In order for Churchland to maintain her materialist position, she must assume a transparency in scientific method, an assumption which is a legacy of Enlightenment philosophy. However, many postmodern philosophers including M. Heidegger and H. G. Gadamer have questioned this assumed transparency of method. The implications of this postmodern philosophy for the current materialistic trends in psychology are discussed. 2012 APA, all rights reserved). (shrink)

How should we live? What do we owe to other people? In Goodness and Advice, the eminent philosopher Judith Jarvis Thomson explores how we should go about answering such fundamental questions. In doing so, she makes major advances in moral philosophy, pointing to some deep problems for influential moral theories and describing the structure of a new and much more promising theory. Thomson begins by lamenting the prevalence of the idea that there is an unbridgeable gap between fact and value--that (...) to say something is good, for example, is not to state a fact, but to do something more like expressing an attitude or feeling. She sets out to challenge this view, first by assessing the apparently powerful claims of Consequentialism. Thomson makes the striking argument that this familiar theory must ultimately fail because its basic requirement--that people should act to bring about the "most good"--is meaningless. It rests on an incoherent conception of goodness, and supplies, not mistaken advice, but no advice at all. Thomson then outlines the theory that she thinks we should opt for instead. This theory says that no acts are, simply, good: an act can at most be good in one or another way--as, for example, good for Smith or for Jones. What we ought to do is, most importantly, to avoid injustice; and whether an act is unjust is a function both of the rights of those affected, including the agent, and of how good or bad the act is for them. The book, which originated in the Tanner lectures that Thomson delivered at Princeton University's Center for Human Values in 1999, includes two chapters by Thomson, provocative comments by four prominent scholars--Martha Nussbaum, Jerome Schneewind, Philip Fisher, and Barbara Herrnstein Smith--and replies by Thomson to those comments. (shrink)

Three decades of concern over consumption of potentially contaminated Great Lakes fish has led government agencies and public health proponents to implement risk assessment and management programs as a means of protecting the health of fishers and their families. While well-meaning in their intent, these programs––and much of the research conducted to support and evaluate them––were not designed to accommodate the understandings and concerns of the fish consumer. Results from a qualitative component of a multi-disciplinary, multi-year research project on frequent (...) (average 108 meals per year) consumers of Great Lakes fish tell the fishers’ side of the story. We present data from 87 tape recorded interviews conducted with Vietnamese, Chinese, and English-speaking participants that underscore the quality of freshly caught Great Lakes fish and the important social and cultural benefits of fish and fishing to the consumer. We also outline the participants’ understandings of risk from eating Great Lakes fish and the way in which fishers and their families manage this risk. The paper concludes with a discussion of these benefits, risks, and risk management strategies as ways that Great Lakes fish consumers “construct” rather than “perceive” risk. We advocate for risk assessment and management protocols that involve those who will be affected the most, such as frequent consumers of Great Lakes fish, from the initial “risk characterization” stage through to any necessary risk communication. (shrink)

What role do science and scientists play in the transition between food regimes? Scientific communities are integral to understanding political struggle during food regime transitions in part due to the broader scientization of politics since the late 1800s. While social movements contest the rules of the game in explicitly value-laden terms, scientific communities make claims to the truth based on boundary work, or efforts to mark some science and scientists as legitimate while marking others as illegitimate. In doing so, scientific (...) communities attempt to establish and maintain the privileged position of science in contests over policy. In this paper, we situate scientific boundary work within its world historical context in order to ask two key questions: (1) how does scientific boundary work vary across food regimes; and, in turn, (2) what role does scientific boundary work play in the political contestation that drives transitions between food regimes? We explore these questions through the case of one scientific community—the AOAC (Association of Official Analytical Communities)—involved in food safety regulation across the British, US, and corporate food regimes. We argue that scientific boundary work is shaped by historically specific patterns of social conflict within food regimes and, in particular, the double-movement dynamics that Polanyi (The great transformation: the political and economic origins of our times. Boston: Beacon, 1957[1944]) theorizes. Moreover, as scientific communities reconstruct their internal rules, norms, and procedures to claim their own legitimacy in relation to prevailing forms of social conflict, they also reshape who sets scientific agendas and thus the knowledge available for making new rules within periods of food regime transition. To elaborate this argument in theoretical terms, we build on recent efforts to integrate a neo-Polanyian perspective into food regime analysis and link this to research on scientific boundary work by scholars in science and technology studies. (shrink)

Recent scholarship has focused on the tensions, contradictions, and limits of place-based branding through labels of origin, place-named agricultural products, and geographical indications. Existing literature demonstrates that even well-intentioned efforts to use place-based branding to protect the livelihoods and cultural and ecological practices of small producers are often undermined by transnational firms, states, and local elites who attempt to capture the benefits of these marketing strategies. Yet, little attention has been given to the implications of place-based branding for competition among (...) geographically dispersed agricultural producers. While place-based branding can be used for emancipatory ends, it can also be used strategically by agricultural producers to expand their market share at the expense of others. To explore these dynamics, I trace an alternative history of place-based branding that begins not in the potentially emancipatory politics of protecting terroir but rather in the tensions and contradictions characterizing the rise and decline of the US food regime. Drawing on a cross-time comparison of branding strategies within the global cotton trade, I make two key arguments. First, I argue that US producers and the US state forged the use of different types of branding strategies in response to the distinct tensions and contradictions characterized by the rise and decline of the US food regime. Second, these distinct branding strategies organized competition among geographically dispersed cotton producers in different ways. (shrink)

We are in an era of uncertainty over whose rules will govern global economic integration. With the growing market share of Chinese firms and the power of the Chinese state it is unclear if Western firms will continue to dominate transnational governance. Exploring these dynamics through a study of contract rules in the global cotton trade, this article conceptualizes commodity chain governance as a contested process of institution-building. To this end, the global commodity chain/global value chain framework must be revised (...) to better account for the broader institutional context of commodity chain governance, institutional variation across space, and strategic action in the construction of legitimate governance arrangements. I provide a more dynamic model of GCC governance that stresses how strategic action, existing institutions, and dominant discourses intersect as firms and states compete for institutional power within a commodity chain. This advances our understandings of how commodity chain governance emerges and changes over time. (shrink)

SummaryMalaria is a major cause of under-five mortality in Mali and many other developing countries. Malaria control programmes rely on households to identify sick children and either care for them in the home or seek treatment at a health facility in the case of severe illness. This study examines the involvement of mothers and other household members in identifying and treating severely ill children through case studies of 25 rural Malian households. A wide range of intra-household responses to severe illness (...) were observed among household members, both exemplifying and contravening stated social norms about household roles. Given their close contact with children, mothers were frequently the first to identify illness symptoms. However, decisions about care-seeking were often taken by fathers and senior members of the household. As stewards of the family resources, fathers usually paid for care and thus significantly determined when and where treatment was sought. Grandparents were frequently involved in diagnosing illnesses and directing care towards traditional healers or health facilities. Relationships between household members during the illness episode were found to vary from highly collaborative to highly conflictive, with critical effects on how quickly and from where treatment for sick children was sought. These findings have implications for the design and targeting of malaria and child survival programming in the greater West African region. (shrink)

This interview with David Kleinberg-Levin, Professor Emeritus in the Department of Philosophy at Northwestern University, concerns his recent trilogy on the promise of happiness in literary language. Kleinberg-Levin discusses the relationship between and among philosophy, phenomenology, and literature. Among others, he addresses questions regarding literature’s ability to offer redemption, its response to suffering and justice, literary gesture, the ethics of narrative logic, and the surface of the text.Cet entretien avec David Kleinberg-Levin, Professeur émérite au département de philosophie de la Northwestern (...) University, est consacrée à sa récente trilogie sur la promesse du bonheur dans le langage littéraire. Kleinberg-Levin examine les relations réciproques et internes de la philosophie, de la phénoménologie et de la littérature. Entre autres, il pose des questions sur la capacité de la littérature à offrir une rédemption, sur sa réponse à la souffrance et à la justice, sur le geste littéraire, sur l’éthique de la logique narrative et sur la surface du texte.L’intervista a David Kleinberg-Levin, Professore Emerito presso il Dipartimento di Filosofia della Northwestern University, è dedicata alla sua recente trilogia sulla promessa di felicità nel linguaggio letterario. Kleinberg-Levin esplora il rapporto tra filosofia, fenomenologia e letteratura. In particolare egli affronta le questioni che riguardano la capacità della letteratura di offrire redenzione, la sua risposta alla sofferenza e alla giustizia, il gesto letterario, l’etica della logica narrativa, e la superficie del testo. (shrink)

This article examines Maurice Merleau-Ponty’s reference to Franz Kafka’s “The Metamorphosis” and “Investigations of a Dog” in his lecture on gesture and reconciliation, “Man Seen from the Outside.” Given the centrality of gesture in Kafka’s work, this essay considers the connections between the two figures and the likely influence of Kafka on Merleau-Ponty’s concept of gesture and intentionality. It compares their respective philosophies of gesture as they relate to meaning, reliability, silence, music, and intention. Finally, Kafka’s gestural motif of the (...) springing body is suggested as a significant example of Merleau-Ponty’s “escaping intentions,” expressing a powerful will to intend toward others.Cet article examine la référence de Maurice Merleau-Ponty à La Métamorphose et aux Recherches d’un chien de Franz Kafka dans sa « causerie » sur le geste et la réconciliation : « L’homme vu du dehors ». Étant-donnée la centralité du geste dans l’oeuvre de Kafka, cet article examine les liens entre les deux auteurs et la possible influence de Kafka sur les concepts merleau-pontiens de geste et d’intentionnalité. Nous comparerons leurs philosophies du geste dans leur manière de se rapporter au sens, à la fiabilité, au silence, à la musique et à l’intention. Enfin, le motif gestuel du corps jaillissant chez Kafka sera proposé comme un exemple significatif des « intentions fuyantes » de Merleau-Ponty, exprimant un puissant désir de se diriger vers les autres.Quest’articolo esamina i riferimenti merleau-pontiani a “La Metamorfosi” e a “Indagini di un cane” di Franz Kafka nella sua conferenza sul gesto e la riconciliazione, “L’uomo visto da fuori”. Data la centralità del gesto nell’opera di Kafka, questo saggio si propone di esaminare le connessioni tra i due autori e la possibile influenza di Kafka sulla concezione merleau-pontiana del gesto e dell’intenzionalità. L’articolo confronta le loro rispettive filosofie del gesto nella misura in cui si riferiscono al significato, alla veridicità, al silenzio, alla musica e all’intenzione. Da ultimo, il motivo gestuale del corpo elastico in Kafka è indagato come significativo esempio delle “intenzioni fuggevoli” merleau-pontiane che esprimono una volontà tesa verso gli altri. (shrink)

_This essay outlines the author’s professional trajectory, a good portion of which is a journey through what historian Richard M. Morse called “the strange career of Latin American Studies.” The author’s intellectual interests span several fields but center most often at the intersections of philosophy, women’s and gender studies, and Spanish and Latin American letters. Further channeling Morse, what one’s occupation is called, is far less important than doing one’s work with _cha cha chá.

In the classic essays Ariel (1900) and Filosofía de la vida artística (1950), the Uruguayan José Enrique Rodó (1872–1917) and the Mexican Samuel Ramos (1897–1959) present distinctive and divergent claims about aesthetics. While Rodó asserts the existence of an innate and abundant aesthetic sensibility among Latin Americans, Ramos believes that aesthetic experience is relatively rare and that aesthetic sensibility needs to be cultivated. While historical grounding in the Latin American context is missing in the works of both Rodó and Ramos, (...) Ariel contains an argument for an innate Latin American aesthetic sensibility linked to high moral development along with the hope that Latin America's youth will use their aesthetic and moral gifts to advance Latin America's place in the 20th century. In Filosofía de la vida artística, Ramos argues that the aesthetic experience in Mexico is far from innate or even widespread: on the contrary, it is rare and much in need of further development. Kant, referenced by both Rodó and Ramos, in his Critique of Judgment, argues against a relationship between aesthetic sensibility and moral capacity. Rodó, then, is at odds with Kant while Ramos's view is closer to Kant's. (shrink)

Leopoldo Zea of Mexico and Miguel de Unamuno of Spain are two exemplary philosophers in twentieth-century transatlantic Hispanism. In this article, these thinkers are put in conversation to explore their contrasting orientations toward existence, which reveal both the breadth of modern Hispanic thought and the benefit of Emilio Uranga’s concept of zozobra, in this case applied by holding in tension the differing approaches of Zea and Unamuno rather than choosing one over the other.

Drawing on a conception of scientists and community members as partners in the construction of ethically responsible research practices, this article urges investigators to seek the perspectives of teenagers and parents in evaluating the personal and political costs and benefits of research on adolescent risk behaviors. Content analysis of focus group discussions involving over 100 parents and teenagers from diverse ethnic and socioeconomic backgrounds revealed community opinions regarding the scientific merit, social value, racial bias, and participant and group harms and (...) benefits associated with surveys, informant reports, intervention studies, blood sampling, and genetic research on youth problems. Participant comments highlight new directions for socially responsible research. (shrink)

Reviews the book, Ethics and values in psychotherapy by Alan C. Tjeltveit . Many psychologists are aware of the ethical and inescapably value-laden nature of psychotherapy . Despite this awareness about values, however, much confusion persists about the nature and management of values in practice. Tjeltveit's text seeks to address such questions among many others. This fine book is one of the first works to comprehensively integrate the research regarding values inescapability with broader ethical theory and philosophy and its potential (...) impact on psychology. In his extensive review, Tjeltveit explores the meaning of "psychotherapist as ethicist," the varied definitions of values, the relationship between science and ethics, the ethical nature of therapy goals and practice, and implications of these issues for public philosophy and professional ethics . Tjeltveit's text is an extremely significant contribution to the discipline, because it is one of the first works to explicitly discuss the value-infused nature of psychotherapy and the consequences that this brings to individual practice, professional standards, and societal expectations. 2012 APA, all rights reserved). (shrink)

Interventions to decrease acquisition and transmission of sexually transmitted diseases among African American women using text messages versus small-group delivery modalities pose distinct research risks and benefits. Determining the relative risk–benefit ratio of studies using these different modalities has relied on the expertise of investigators and their institutional review boards. In this study, African American women participated in focus groups and surveys to elicit and compare risks and benefits inherent in these two intervention delivery modalities, focusing on issues such as (...) convenience, privacy, and stigma of participation. Some risk/benefit variables were implicated in willingness to participate the two intervention modalities. (shrink)

Lee emphasizes the need to better understand the moral relationship between researchers and participants connoted by precision medicine, with the framework of “the gift” offering bioethics a...

A vision of a living code of ethics is proposed to counter the emphasis on negative phenomena in the study of organizational ethics. The living code results from the harmonious interaction of authentic leadership, five key organizational processes (attraction–selection–attrition, socialization, reward systems, decision-making and organizational learning), and an ethical organizational culture (characterized by heightened levels of ethical awareness and a positive climate regarding ethics). The living code is the cognitive, affective, and behavioral manifestation of an ethical organizational identity. We draw (...) on business ethics literature, positive organizational scholarship, and management literature to outline the elements of positive ethical organizations as those exemplary organizations consistently practicing the highest levels of organizational ethics. In a positive ethical organization, the right thing to do is the only thing to do. (shrink)

Background: Recent research demonstrates that people sometimes make different medical decisions for others than they would make for themselves. This finding is particularly relevant to end-of-life decisions, which are often made by surrogates and require a trade-off between prolonging life and maintaining quality of life. We examine the impact of decision role, patient age, decision maker age and multiple individual differences on these treatment decisions. Methods: Participants read a scenario about a terminally ill cancer patient faced with a choice between (...) an aggressive chemotherapy regimen that will extend life by two years and palliative treatments to control discomfort for one remaining month. Participants were randomly assigned to one of three decision roles (patient, physician, or an abstract other) and the scenario randomly varied whether the patient was described as 25 or 65-years old. Results: When deciding for a 65-year old patient, approximately 60% of participants selected aggressive chemotherapy regardless of decision role. When deciding for a 25-year old patient, however, participants were more likely to select chemotherapy for a patient (physician role) or another person (abstract other) than for themselves (70%, 67%, and 59%, respectively). In addition, confidence that powerful others (eg, physicians) control one’s health, as well as respondents’ age and race, consistently predicted treatment choices. Conclusions: Patient age appears to influence medical decisions made for others but not those that we make for ourselves. These findings may help to explain the discord that often occurs when younger cancer patients refuse life-extending treatments. (shrink)

In this article, we examine the link between board composition and an enterprise strategy outcome, stakeholder relations. Because a firm’s enterprise strategy is set at the highest level of the organization, we expect the presence of stakeholder directors (suppliers, customers, employees, and community representatives) to be positively associated with stakeholder performance.Results from an analysis of 3,268 board members representing 250 firms are discussed in the context of both corporate governance and stakeholder management literatures.

Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons. We identify participant-centricity and trustworthiness as the most important features of an MIC and discuss the implications for those seeking to create a sustainable, useful, and widely available collection of linked resources for research and other purposes.

It is common in philosophy of language to recognise two different kinds of linguistic meaning: literal or conventional meaning, on the one hand, versus communicated or conveyed meaning, on the other. However, once we recognise these two types of meaning, crucial questions immediately emerge; for instance, exactly which meanings should we treat as the literal (semantic) ones, and exactly which appeals to a context of utterance yield communicated (pragmatic), as opposed to semantic, content? It is these questions and, specifically, how (...) we should model the relationship between semantic content and utterance context, that is the topic of this chapter. We explore five contemporary answers to this modelling question, considering the benefits and challenges of each, before closing by examining some potential new directions for debates in this area. (shrink)

Ruhollah Khomeini views on clergy and professional ethics.

Amit Sharma, Rajesh Ramanathan, Marc Posner, Robert A Fisher Hume-Lee Transplant Center, Virginia Commonwealth University, Richmond, VA, USA: Pediatric kidney transplantation is the preferred treatment for children with end-stage renal disease. The most common indications for transplantation in children are renal developmental anomalies, obstructive uropathy, and focal segmental glomerulosclerosis. Living donor kidney transplants are often performed pre-emptively and offer excellent graft function. Policy changes in deceased-donor kidney allocation have increased the proportion of such transplants in pediatric recipients. Adequate pretransplant (...) workup along with evaluation of urologic abnormalities is imperative in achieving good outcomes. Overall, patient and graft outcomes after kidney transplantation have improved, with five-year deceased donor and living donor graft survivals of 78.8% and 84.3%, respectively. Improvements in induction and maintenance immunosuppression have contributed to the gradual improvement in outcomes. Unique challenges in pediatric recipients include increased graft thrombosis, adverse growth, and abnormal development relating to immunosuppression, increased rejection due to nonadherence, increased susceptibility to opportunistic infections, and post-transplant malignancy. This review focuses on the current practices and outcomes in pediatric kidney transplantation in North America. We discuss the indications for transplantation, the evaluation process, some key surgical and immunologic considerations, and the common risk factors for graft dysfunction. Keywords: pediatric kidney transplantation, end-stage renal disease, dialysis, organ donors, immunosuppression. (shrink)

We examined whether midazolam impairs short-term/working memory processes. We hypothesize that prior dissociations in midazolam’s effects on short-term/working memory tasks and episodic memory tasks arise because midazolam has a larger effect on episodic memory processes than on short-term/working memory processes. To examine these issues, .03 mg/kg of participant’s bodyweight of midazolam was administered in a double-blind placebo-controlled within-participant design. Performance on the digit span and category generation/recall tasks was examined. The results of Experiment 1 demonstrated that: midazolam impaired performance on (...) the digit span task; midazolam did not impair performance on the category generation task; midazolam impaired performance on the category recall task; and midazolam’s effect on category recall was four times as large as its effect on digit span. The results of Experiment 2 demonstrated that midazolam did not impair digit span performance when the digit span task was administered at a later time. These results suggest that midazolam can impair short-term/working memory processes, but these effects are substantially smaller than midazolam’s effect on episodic memory processes. Moreover, they demonstrate that conscious awareness of materials during study is not sufficient to produce episodic memory. (shrink)